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lenvatinib/Cas:417716-92-8 /lenvatinib Mesylate 857890-39-2 CAS NO.417716-92-8
- FOB Price: USD: 4.00-5.00 /Metric Ton Get Latest Price
- Min.Order: 25 Metric Ton
- Payment Terms: L/C,D/P,T/T,
- Available Specifications:
100(1-25)Metric Ton100(100-500)Metric Ton
- Product Details
Keywords
- 417716-92-8
- 857890-39-2
- lenvatinib
Quick Details
- ProName: lenvatinib/Cas:417716-92-8 /lenvatinib...
- CasNo: 417716-92-8
- Molecular Formula: C21H19ClN4O4·CH4O3S
- Appearance: White or off white powder
- Application: It is suitable for chemical industry s...
- DeliveryTime: ccording to the actual situation
- PackAge: 100g/bag 1kg/bag 25kg/barrels
- Port: Shanghai port, shenzhen port, tianjin ...
- ProductionCapacity: 100 Metric Ton/Day
- Purity: 99%
- Storage: 2 ℃, 25 ℃ dry dark cold storage
- Transportation: Air freight; shipping；DHL;FEDEX;TNT…
- LimitNum: 25 Metric Ton
- Related Substances: Refer to the details
- Residue on Ignition: Refer to the details
- Heavy Metal: ≤20ppm
- Valid Period: 24 month
- Total protein content: 99%
Superiority
Anticancer drugs lovastatin E7080 price regular manufacturers
Lovastinib E7080
4-[3- chloro -4- (cyclopropyl amino carbonyl) amino phenoxy]-7- methoxy -6- quinoline formamide
Lovastatin
English Name: lenvatinib
English aliases: E7080, E7080; Lenvatinib (E7080); 4-[3-chloro-4-(cyclopropylcarbamoylamino) phenoxy]-7-methoxyquinoline-6-carboxamide; Lenvatinib;
CAS: 417716-92-8
Molecular formula: C21H19ClN4O4
Molecular weight: 426.85300
Exact mass: 426.10900 PSA:115.57000 LogP:5.23610
Density: 1.469g/cm3
Boiling point: 627.242 C at 760 mmHg
Flash point: 333.144 x C
Refractive index: 1.697
Content: 99.5%
Purpose: anticancer drugs for liver cancer (for scientific research only).
E7080 (Lenvatinib) is a multi-target inhibitor. It is effective on the expression of VEGFR2 (KDR)/VEGFR3 (Flt-4)*** and IC50 is 4 nM/5.2. It has a slightly weaker effect on the expression of VEGFR1/Flt-1. The selectivity of PDGFRa/beta is about 10 times higher than that of the expression of FGFR1.
In vitro study: E7080 effectively inhibited angiogenesis and significantly inhibited VEGF/KDR and SCF/KIT signaling pathways. According to in vitro receptor tyrosine and serine/threonine kinase experiments, when E7080 inhibited Flt-1, KDR and Flt-4, IC50 was 22, 4.0 and 5.2 nM, respectively. In addition to these kinases, E7080 also inhibits both fibroblast growth factor 1 and PDGFR tyrosine kinases. When acting on fibroblast growth factor 1, PDGFR alpha and PDGFR beta, IC50 is 46, 51 and 100 nM, respectively. [1] E7080 acted on HUVECs stimulated by vascular endothelial growth factor and vascular endothelial growth factor-C respectively, effectively inhibiting phosphorylation of vascular endothelial growth factor R2 and vascular endothelial growth factor R3, IC50 being 0.83 nM and 0.36 nM, respectively. Recent studies have shown that treatment with 1um and 10um M E7080 significantly inhibits cell migration and invasion by inhibiting the signal pathways of FGFR and PDGFR.
In vivo studies: E7080 was administered orally at doses of 30 and 100 mg to treat H146 transplanted tumor model, inhibiting the growth of H146 tumor. This effect was dose-dependent, and led to tumor decline at doses of 100 mg. Moreover, E7080 at a dose of 100 mg reduced microvessel density more than those treated with anti-VEGF antibody and Imatinib.
Characteristics: E7080 is an effective oral multitarget kinase inhibitor.
Lovastinib E7080
4-[3- chloro -4- (cyclopropyl amino carbonyl) amino phenoxy]-7- methoxy -6- quinoline formamide
Lovastatin
English Name: lenvatinib
English aliases: E7080, E7080; Lenvatinib (E7080); 4-[3-chloro-4-(cyclopropylcarbamoylamino) phenoxy]-7-methoxyquinoline-6-carboxamide; Lenvatinib;
CAS: 417716-92-8
Molecular formula: C21H19ClN4O4
Molecular weight: 426.85300
Exact mass: 426.10900 PSA:115.57000 LogP:5.23610
Density: 1.469g/cm3
Boiling point: 627.242 C at 760 mmHg
Flash point: 333.144 x C
Refractive index: 1.697
Content: 99.5%
Purpose: anticancer drugs for liver cancer (for scientific research only).
E7080 (Lenvatinib) is a multi-target inhibitor. It is effective on the expression of VEGFR2 (KDR)/VEGFR3 (Flt-4)*** and IC50 is 4 nM/5.2. It has a slightly weaker effect on the expression of VEGFR1/Flt-1. The selectivity of PDGFRa/beta is about 10 times higher than that of the expression of FGFR1.
In vitro study: E7080 effectively inhibited angiogenesis and significantly inhibited VEGF/KDR and SCF/KIT signaling pathways. According to in vitro receptor tyrosine and serine/threonine kinase experiments, when E7080 inhibited Flt-1, KDR and Flt-4, IC50 was 22, 4.0 and 5.2 nM, respectively. In addition to these kinases, E7080 also inhibits both fibroblast growth factor 1 and PDGFR tyrosine kinases. When acting on fibroblast growth factor 1, PDGFR alpha and PDGFR beta, IC50 is 46, 51 and 100 nM, respectively. [1] E7080 acted on HUVECs stimulated by vascular endothelial growth factor and vascular endothelial growth factor-C respectively, effectively inhibiting phosphorylation of vascular endothelial growth factor R2 and vascular endothelial growth factor R3, IC50 being 0.83 nM and 0.36 nM, respectively. Recent studies have shown that treatment with 1um and 10um M E7080 significantly inhibits cell migration and invasion by inhibiting the signal pathways of FGFR and PDGFR.
In vivo studies: E7080 was administered orally at doses of 30 and 100 mg to treat H146 transplanted tumor model, inhibiting the growth of H146 tumor. This effect was dose-dependent, and led to tumor decline at doses of 100 mg. Moreover, E7080 at a dose of 100 mg reduced microvessel density more than those treated with anti-VEGF antibody and Imatinib.
Characteristics: E7080 is an effective oral multitarget kinase inhibitor.
Packaging Specification: 25kg/drum
Hubei DiBo Chemical Co., Ltd. was founded in 2009, is a high-tech industrial unit which integrates R&D, production and sales.
Yunmeng is mainly engaged in R & D and marketing of pharmaceutical raw materials and intermediates. Main Products: Anti-tumor, anti-bacterial and anti-inflammatory, hormones, positive, enzyme preparations and other high-tech products.
Jingzhou is mainly engaged in the manufacture of agro chemicals. Main products: herbicides, fungicides, pesticides and rodents, plant growth regulation, feed additives and other related agricultural and chemical products.
Details
1.high quality and competetive price
1)for Pharmaceutical raw materials exported we can offer coa certificate and official invoice.
2)we are manufacturer with own lab and factory, can provide high quality products with factory price.
3)products purity is test by our quality department strictly before sending, and you can also ask the third testing organization come and inspect, such as (sgs/ cti/ its), only after your confirmation will we send it out to you.
2.fast and safe delivery:
1)products can be sent out one or four weeks after payment. tracking number available, fixed service person are 7x24h for you to contact.
2) secure and discreet shipment. various transportation methods for your choice, like dhl/ups/tnt/fedex/sf-express.
3)customs pass and satisfied rate ¡ý99%.
4)for hot sale products we have stock in there for transferring.
3 we have clients throughout the world:
1) professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.
3) high quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
